Table 1.
Serum Metabolites Significantly Different for HFD vs Chow (N = 3)
| Sample ID | HFD | HFD | HFD | Chow | Chow | Chow | Fold-change | P |
|---|---|---|---|---|---|---|---|---|
| Shikimate | 1,089,275 | 1,687,554 | 1,774,052 | 24,346,440 | 36,264,443 | 37,236,094 | 0.04651 | 0.0017 |
| 3-Methylphenylacetic acid | 50,374.47 | 12,528.38 | 37,123.99 | 261,828.1 | 374,982.6 | 540,307.4 | 0.08498 | 0.0117 |
| 2-Aminooctanoic acid | 3,705,619 | 3,336,997 | 3,106,194 | 6,186,280 | 11,259,663 | 8,351,355 | 0.39341 | 0.02436 |
| N-acetyl-glutamine | 348,255.6 | 1,368,072 | 741,499.4 | 1,862,150 | 2,034,418 | 1,530,678 | 0.45287 | 0.04058 |
| Maleic acid | 1,894,292 | 1,763,624 | 2,659,257 | 3,979,273 | 4,135,781 | 4,259,294 | 0.51051 | 0.00226 |
| Fumarate | 1,886,339 | 1,688,418 | 2,866,039 | 4,116,645 | 3,979,963 | 4,342,941 | 0.51777 | 0.0062 |
| 2-Keto-isovalerate | 1,876,718 | 1,848,292 | 2,531,636 | 3,828,446 | 3,989,420 | 4,239,557 | 0.5189 | 0.00158 |
| Malate | 13,036,534 | 13,338,714 | 20,444,932 | 25,481,291 | 27,355,471 | 28,282,788 | 0.57718 | 0.01106 |
| 2-Isopropylmalic acid | 435,794.8 | 544,200.1 | 501,269.3 | 716,197.6 | 850,253.7 | 806,456 | 0.62424 | 0.00417 |
| Hydroxyproline | 1,129,533 | 971,637.6 | 1,400,073 | 1,754,945 | 2,126,389 | 1,698,862 | 0.62744 | 0.01947 |
| Serine | 10,864,799 | 9,120,770 | 9,096,639 | 6,100,208 | 6,902,703 | 6,321,955 | 1.50491 | 0.00678 |
| 4-Aminobutyrate | 19,742.1 | 18,701.03 | 14,974.13 | 11,219.59 | 11,486.34 | 12,302.38 | 1.52585 | 0.01442 |
| Purine | 444,057.3 | 496,184.5 | 421,698 | 254,463.2 | 323,655.7 | 313,140 | 1.52811 | 0.00703 |
| Uridine | 774,870.4 | 1,007,281 | 1,010,560 | 534,301.5 | 624,173.9 | 588,797.5 | 1.59833 | 0.01332 |
| Methylcysteine | 2,116,275 | 2,522,708 | 2,473,738 | 1,321,345 | 1,693,198 | 1,307,515 | 1.64568 | 0.00665 |
| Deoxyuridine | 166,050.2 | 190,394.9 | 184,623.3 | 113,833.8 | 120,865.1 | 891,59.99 | 1.67069 | 0.00392 |
| Aminoimidazole carboxamide ribonucleotide | 11,724.92 | 9084.187 | 12,305.94 | 4272.649 | 6163.236 | 5877.462 | 2.02994 | 0.00829 |
| Kynurenic acid | 303,590.8 | 406,552.9 | 254,063.9 | 144,964.3 | 155,164.5 | 159,147.8 | 2.09941 | 0.02028 |
| Ornithine | 11,732,045 | 11,815,352 | 7,731,882 | 3,400,980 | 6,215,043 | 5,270,134 | 2.10123 | 0.0259 |
| Dimethylglycine | 6,246,739 | 9,722,711 | 6,381,083 | 3,568,381 | 3,546,751 | 3,498,425 | 2.10585 | 0.02628 |
| Homocysteine | 67,440.13 | 58,050.68 | 51,315.81 | 27,962.43 | 20,051.53 | 34,720.26 | 2.13704 | 0.00766 |
| Nicotinamide | 21,645,145 | 16,344,710 | 14,481,236 | 1,928,119 | 8,393,518 | 8,048,776 | 2.85628 | 0.01934 |
| 3-S-methylthiopropionate | 332,935.7 | 323,819.6 | 400,830.5 | 68,402.46 | 111,655.7 | 113,215.4 | 3.60614 | 0.00085 |
| N1-methyl-2_4-pyridone-3_5-carboximide | 21,978.47 | 23,191.8 | 27,399.03 | 3000 | 5991.789 | 4821.317 | 5.25366 | 0.00046 |
| Pantothenate | 126,600.8 | 111,466.3 | 71,988.17 | 11,066.49 | 15,090.77 | 19,685.47 | 6.76346 | 0.00589 |