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. 2017 Jul 26;158(10):3269–3280. doi: 10.1210/en.2017-00500

Figure 6.

Figure 6.

Group data (mean ± SEM; n = 6 in all) showing that senktide infusion into the S-ME stimulated kisspeptin release in prepubertal and pubertal monkeys. Animals were treated with (A, B) 0.1 µM senktide, (C, D) 10 µM senktide, and (E, F) vehicle. In the prepubertal group, both 0.1 µM and 10 µM senktide significantly (P < 0.01 and P < 0.0001, respectively) increased kisspeptin release over the baseline levels, and the effects of senktide at both doses were significantly larger (P < 0.01 for 0.1 µM and P < 0.0001 for 10 µM) than those in vehicle. Similarly, in pubertal monkeys, both 0.1 µM and 10 µM senktide significantly (P < 0.001 and P < 0.0001, respectively) stimulated kisspeptin release over the baseline levels, and the effects of senktide at both doses were also significantly larger (P < 0.001 for 0.1 µM and P < 0.0001 for 1 µM) than those in vehicle. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs vehicle infusion; #P < 0.05, ##P < 0.01, ###P < 0.001, ####P < 0.0001 vs before infusion.