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. 2017 Jul 26;158(10):3269–3280. doi: 10.1210/en.2017-00500

Figure 7.

Figure 7.

Representative cases and group data (mean ± SEM) showing modification of the 0.1 µM senktide-induced GnRH release by the kisspeptin antagonist P234 (0.1 µM) in prepubertal and pubertal monkeys. Senktide induced GnRH release in the absence of P234 in both (C) prepubertal (P < 0.01) and (D) pubertal (P < 0.001) monkeys when compared with baseline or vehicle infusion GnRH levels. However, in the presence of P234, the senktide-induced GnRH release was absent in (F) pubertal monkeys (P > 0.05), whereas in prepubertal monkeys, senktide induced GnRH release with a 20-minute delay. The senktide-induced GnRH release in (C) prepubertal monkeys was significantly larger (P < 0.0001) than baseline GnRH levels. (G, H) In both stages, P234 alone did not alter GnRH release. **P < 0.01, ***P < 0.001, ****P < 0.0001 vs vehicle infusion; ##P < 0.01, ###P < 0.001, ####P < 0.0001 vs before infusion.