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. 2017 Aug 14;158(10):3629–3646. doi: 10.1210/en.2016-1617

Figure 1.

Figure 1.

Effect of short-term NVP-BGJ398 administration on serum and urinary biochemical markers in Vector and HMWTg mice. Five- to six-week-old Vector or HMWTg mice received a single oral dose of the FGFR inhibitor NVP-BGJ398 (50 mg/kg, oral) or vehicle and were studied 7 or 24 hours after administration of NVP-BGJ398. Vector mice were treated with vehicle only. Serum was collected during euthanasia. (a) Serum calcium, (b) Pi, and (c) creatinine levels were measured. (d) Spot urine samples were collected during euthanasia and PEI was determined. (e) Serum intact FGF23, (f) serum 1,25(OH)2D3, (g) serum αKlotho, and (h) serum PTH levels were determined by enzyme-linked immunosorbent assay. (i) Whole femur Fgf23 mRNA level and (j) kidney Npt2a mRNA level were analyzed by quantitative polymerase chain reaction. Data are mean ± SE, n = 4 to 7 per group. *Compared with Vector-Vehicle group, P < 0.05; #Compared with HMWTg-Vehicle group, P < 0.05.