Table 1.
Bone Histomorphometry Analysis of Femoral Trabecular Bone
| Static | Vector Vehicle (n = 9) | HMW Vehicle (n = 9) | HMW NVP-BGJ398 (n = 5) |
|---|---|---|---|
| BV/TV, % | 4.98 ± 0.72 | 2.95 ± 0.56a | 3.25 ± 0.80 |
| TbTh, μm | 25.65 ± 1.67 | 24.19 ± 1.88 | 22.90 ± 1.54 |
| ObS/BS, % | 9.36 ± 1.73 | 9.96 ± 1.10 | 6.83 ± 1.13b |
| OcS/BS, % | 11.94 ± 2.14 | 19.10 ± 2.51a | 23.05 ± 3.76b |
| OcN/BS,1/mm | 3.32 ± 0.55 | 5.04 ± 0.56a | 5.38 ± 0.76b |
| TbN, 1/mm | 1.91 ± 0.18 | 1.19 ± 0.19a | 1.37 ± 0.26 |
| TbSp, μm | 534.5 ± 49.5 | 1062.4 ± 215.2a | 815.6 ± 143.8b |
| Dynamic | Vector Vehicle (n = 8) | HMW Vehicle (n = 9) | HMW NVP-BGJ398 (n = 8) |
| Interlabel thickness, u | 7.54 ± 0.47 | 7.31 ± 0.46 | 8.88 ± 0.47c |
| Mineralizing surface/BS, % | 21.64 ± 1.47 | 24.09 ± 1.25 | 25.80 ± 1.64 |
| Mineral apposition rate, μm/d | 1.51 ± 0.09 | 1.46 ± 0.09 | 1.78 ± 0.09c |
| Bone formation rate/BS, u3/u2/d | 0.32 ± 0.02 | 0.35 ± 0.02 | 0.46 ± 0.04b,c |
Abbreviations: ObS, osteoblast surface; OcN, osteoclast number; OcS, osteoclast surface; TbN, trabecular number; TbSp, trabecular separation; TbTh, trabecular thickness.
a
Vector-Vehicle vs HMW-Vehicle, P < 0.05.
b
Vector-Vehicle vs HMW-BGJ398, P < 0.05.
c
HMW-Vehicle vs HMW-BGJ398, P < 0.05.