Figure 1.
sNR DBD mutant mouse models. (a) Two ERα DBD mutant mouse models of ERα: two point mutations at amino acids E207A and G208A in the P-box of the first zinc finger (ERα-KIKO) and four point mutations at amino acids Y201E, K210A, K214A, and R215E that flank the P-box of the first zinc finger (ERα-EAAE). (b) GR DBD mutant mouse model of the GR: an A458T point mutation introduced into the second zinc finger (GR-Dim).
