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. 2017 Jul 20;158(10):3212–3234. doi: 10.1210/en.2017-00468

Figure 1.

Figure 1.

sNR DBD mutant mouse models. (a) Two ERα DBD mutant mouse models of ERα: two point mutations at amino acids E207A and G208A in the P-box of the first zinc finger (ERα-KIKO) and four point mutations at amino acids Y201E, K210A, K214A, and R215E that flank the P-box of the first zinc finger (ERα-EAAE). (b) GR DBD mutant mouse model of the GR: an A458T point mutation introduced into the second zinc finger (GR-Dim).