Skip to main content
. 2017 Jul 20;158(10):3212–3234. doi: 10.1210/en.2017-00468

Table 1.

Number of 0- to 3-nt Variant ERE and HRE Motifs in the Mouse and Human Genomes ERE =GGT¯CAnnnTGAC¯C1 2 3 4 5  6 7 8 9 10 HRE =GAA¯CAnnnTGTT¯C1 2 3 4 5  6 7 8 9 10

Combinatorial Counts
 Actual Motif Frequency in Genomes
A
 B
 C
 D
 E
 F
 Mouse Genome (mm10)
 Human Genome (hg19)
ERE Comb. C = (nk) 4 nts D = C × 4A Total Unique E = ΣF Unique F = C × 3A Total Unique Unique Total Unique Unique
0 Perfect ERE 1 1 1 1 2367 2194
1 1-nt Variant ERE 10 40 31 30 73,795 71,428 62,507 60,313
2 2-nt Variant ERE 45 720 436 405 971,950 898,155 977,233 914,726
3 3-nt Variant ERE 120 7680 3676 3240 7,722,557 6,750,607 8,493,417 7,516,184
A
 B
 C
 D
 E
 F
 Mouse Genome (mm10)
 Human Genome (hg19)
HRE Comb. C = (nk) 4 nts D = C × 4A Total Unique E = ΣF Unique F = C × 3A Total Unique Unique Total Unique Unique
0 Perfect HRE 1 1 1 1 3444 3535
1 1-nt Variant HRE 10 40 31 30 100,483 97,039 108,302 104,767
2 2-nt Variant HRE 45 720 436 405 1,437,999 1,337,516 1,447,845 1,339,543
3 3-nt Variant HRE 120 7680 3676 3240 11,899,196 10,461,197 12,219,004 10,771,159
A
 B
 C
 D
 E
 F
Comb. C = (nk)
4 nts D = C × 4A
Total Unique E = ΣF
Unique F = C × 3A
0 Perfect 10!/(0! × 10!) 1 × 1 (3° × 1) + 0 (3° × 1)
1 1-nt Variant 10!/(1! × 9!) 10 × 4 (31 × 10) + 1 (31 × 10)
2 2-nt Variant 10!/(2! × 8!) 45 × 16 (32 × 45) + 31 (32 × 45)
3 3-nt Variant 10!/(3! × 7!) 120 × 64 (33 × 120) + 436 (33 × 120)

The number of 0- to 3-nt variants of the ERE and HRE on the positive/sense strand identified in the mouse (mm10) and human (hg19) genomes using OligoMatch (University of California, Santa Cruz). Here ERE is the estrogen response element (5′-GGTCAnnnTGACC-3′) and HRE is the hormone response element (5′-GAACAnnnTGTTC-3′). The 0- to 3-nt variants include the 1 unique perfect consensus element, 30 1-nt variants, 405 2-nt variants, and 3240 3-nt variants, for a total of 3676 sequences.