Table 2.

Clinician- and subject-rated scores on mood and clinical improvement outcomes by TIB condition.

					Analysis
Measure and Assessment	8h TIB (n=19)		6h TIB (n=49)		β estimate§	SE	p value
Clinician-Rated	Mean	SD	Mean	SD
HAMD-17 (minus sleep items)a
Baseline	18.2	2.6	18.0	2.2
Week 1	13.2	4.0	15.1	4.1	2.2	1.6	0.20
Week 2	11.3	3.4	13.9	5.3	2.9	1.6	0.08
Week 3	6.9	3.5	11.8	5.0	5.8	1.6	0.001
Week 4	8.5	5.5	11.0	5.2	2.9	1.6	0.07
Week 5	7.2	4.7	10.6	6.4	3.8	1.6	0.02
Week 6	4.9	4.8	8.7	5.4	4.4	1.6	0.006
Week 7	6.4	5.5	8.9	6.0	2.6	1.6	0.09
Week 8	6.1	6.7	7.1	4.7	1.2	1.3	0.35
CGI - Improvement
Week 1	3.2	1.3	3.2	0.7
Week 2	2.7	0.6	2.9	0.9	0.2	0.3	0.66
Week 3	2.1	0.8	2.8	1.1	0.7	0.3	0.04
Week 4	2.3	1.2	2.6	1.0	0.3	0.3	0.42
Week 5	2.4	1.4	2.5	1.2	0.1	0.3	0.67
Week 6	1.8	1.0	2.2	1.0	0.5	0.4	0.14
Week 7	1.9	1.1	2.1	0.9	0.3	0.3	0.44
Week 8	1.8	1.0	1.8	0.8	0.06	0.3	0.84
Subject-Rated
QIDS-SR (minus sleep item)b
Baseline	10.8	3.3	11.4	4.0
Week 1	6.5	4.4	9.2	4.4	1.9	1.3	0.15
Week 2	5.1	2.9	7.8	4.0	2.3	1.3	0.07
Week 4	4.9	3.5	6.7	3.8	1.2	1.2	0.33
Week 8	3.6	4.4	5.0	3.9	0.8	1.1	0.45
SF-12: Physical Composite
Baseline	55.8	5.3	54.7	10.0
Week 4	56.1	4.9	51.9	9.2	−1.2	2.5	0.65
Week 8	53.7	6.6	53.3	8.2	1.5	2.6	0.56
SF-12: Mental Composite
Baseline	24.8	9.1	26.8	8.3
Week 4	38.5	14.7	34.4	11.2	−6.2	3.5	0.08
Week 8	44.8	12.5	40.0	11.2	−7.9	3.8	0.04

^aHAMD-17 minus sleep range is 0–46;

^bQIDS-SR minus sleep range is 0–24;

^§β estimate comparing 8h TIB vs. combined 6h TIB conditions with Baseline as reference (Visit 1 reference for CGI-I).

Note: boldface type denotes significant findings

Abbreviations

CGI=Clinical Global Impressions scale

HAMD-17= 17-item Hamilton Rating Scale for Depression

QIDS-SR=Quick Inventory of Depressive Symptomatology-Self-Rated

SF-12= 12-Item Short-Form Health Survey

6h TIB = 6 hours time in bed

8h TIB = 8 hours time in bed