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. Author manuscript; available in PMC: 2017 Oct 27.
Published in final edited form as: J Med Chem. 2017 Sep 18;60(18):7820–7834. doi: 10.1021/acs.jmedchem.7b00952

Figure 2.

Figure 2

Three-dimensional structures of TTR·ligand complexes that contain a boronic acid group. One monomer (chain B) of the TTR tetramer is shown, and is in the same orientation in each panel. The main chain of TTR is rendered as a ribbon, and the side chains of Lys15 and Ser117 are shown explicitly. Ligands are depicted in a ball-and-stick rendition with CPK coloring and boron atoms labeled explicitly. Alternative conformations of Ser117 or the ligand are shown in some panels. Arrows indicate the O117γ–B bond in the TTR·10 and TTR·11 complexes. Images were created with the program PyMOL. (A) TTR·2 (PDB entry 5u48). (B) TTR·4 (5u4a). (C) TTR·6 (5u4c). (D) TTR·8 (5u4e). (E) TTR·10 (5u4f). (F) TTR·11 (5u4g).