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. Author manuscript; available in PMC: 2017 Oct 27.
Published in final edited form as: J Med Chem. 2017 Sep 18;60(18):7820–7834. doi: 10.1021/acs.jmedchem.7b00952

Figure 3.

Figure 3

Three-dimensional structures of TTR·ligand complexes that do not contain a boronic acid group. One monomer of the TTR tetramer is shown, and is in the same orientation in each panel. The main chain of TTR is rendered as a ribbon, and the side chains of Lys15 and Ser117 are shown explicitly. Ligands are depicted in a ball-and-stick rendition with CPK coloring. Alternative conformations of Ser117 or the ligand are shown in panels B and C. Images were created with the program PyMOL. (A) TTR·3 (PDB entry 5u49, chain A). (B) TTR·5 (5u4b, chain B). (C) TTR·7 (5u4d, chain B).