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. Author manuscript; available in PMC: 2017 Oct 27.
Published in final edited form as: J Med Chem. 2017 Sep 18;60(18):7820–7834. doi: 10.1021/acs.jmedchem.7b00952

Figure 4.

Figure 4

Halogen-bonding interactions in the TTR·10 and TTR·11 complexes. One monomer (chain B) of the TTR tetramer is shown. Chloro groups in the two ester-forming boronates exhibit C–Cl···O108′ angles that are nearly linear and Cl··· O108′ distances (dashed yellow lines) that are 3.6–3.8 Å (Table S12). Images were created with the program PyMOL. (A) TTR·10 (PDB entry 5u4f). (B) TTR·11 (5u4g).