Table 1.

Interaction of Diphenols 1–4 with Wild-type TTR and its V30M Variant

compound	Kd,2 (μM)	wild-type TTR		V30M TTR		binding modeb
		%FF 1:1a	%FF 2:1a	%FF 1:1a	%FF 2:1a
1 (resveratrol)	0.47 ± 0.03	28 ± 8	9 ± 2	53 ± 12	26 ± 4	forward
2	0.47 ± 0.02	21 ± 4	9 ± 2	48 ± 11	23 ± 6	reverse
3	0.73 ± 0.02	22 ± 4	7 ± 3	44 ± 10	14 ± 4	forward
4	0.44 ± 0.01	19 ± 4	4 ± 2	36 ± 8	12 ± 3	reverse

^a%FF, percent fibril formation.

^b”forward”: upper phenyl ring depicted in Chart 1 lies in the outer pocket of the T₄-binding site, according to X-ray diffraction analysis (Figures 2 and 3); “reverse”: upper ring lies in the inner pocket.¹⁸