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. Author manuscript; available in PMC: 2018 Sep 25.
Published in final edited form as: Curr Biol. 2017 Sep 7;27(18):2869–2877.e6. doi: 10.1016/j.cub.2017.08.019

Fig 3. Lh VLPs are enriched in microvesicular/exosomal and membrane-associated proteins.

Fig 3

(A) Select example Lh VLP proteins, many of which are expected to be membrane-associated via integral or other biochemical mechanisms, are displayed by their proteomic Classes 1 – 3 (bulleted within descriptive subclasses). Example subclasses and individual proteins found in enrichment analyses (B, C) are shown in red. AGT = anterograde transport; RGT = retrograde transport. (B, C) Enrichments from Vesiclepedia: The organelle character of Lh VLPs based on GO Terms of predicted orthologs is (B) significant and (C) highly enriched. (B) Among VLP proteins with annotated orthologs, 71% are mitochondrial, of which 12% are localized to the mitochondrial inner membrane. Approximately 50% of conserved sequences in the proteome are common to microvesicles/exosomes. (C) Vesicular and mitochondrial, including that of the caspase complex, terms are the most over-represented. Furthermore, genes within the GO Term (GO:0008303) for pro-apoptotic caspase complexes were more than 200 times over-represented. (See also Tables S1, S2.)