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. Author manuscript; available in PMC: 2019 Jan 30.
Published in final edited form as: Behav Brain Res. 2017 Sep 18;337:34–45. doi: 10.1016/j.bbr.2017.09.026

Figure 4. Motor learning is affected in male, but not female, HdhQ350/+ mice.

Figure 4

Fast motor learning was calculated by improved performance between the first and last trial on day 1. Slow motor learning was calculated by cumulative improved performance over all 3 days (See Materials and Methods). (A) HdhQ350/+ males showed significantly enhanced fast motor learning while (B) HdhQ350/+ females did not. (C) Comparison of male HdhQ350/+ mice to female HdhQ350/+ mice when normalized to their respective wild-type littermates in fast motor learning revealed no difference between sexes. (D) HdhQ350/+ males showed significantly enhanced slow motor learning while (E) HdhQ350/+ females did not differ from their respective wild-type littermates. (F) Comparison of male HdhQ350/+ mice to female HdhQ350/+ mice when normalized to their respective wild-type littermates revealed a significant difference in slow motor learning between sexes. N=8 for all groups. Error bars represent S.E.M. and *p<0.05, **p<0.01, with two-way ANOVA with Bonferroni post-hoc test.