Table 3.

Inflammatory versus Non-Inflammatory CSF profile and risk of relapse following a brain biopsy-confirmed TDL. Inflammatory CSF profile was defined as having elevated IgG Index or ≥2 oligoclonal bands. Non-inflammatory CSF was defined by normal IgG Index and <2 oligoclonal bands.

	No inflammation on CSF Exam (n=11)	Intrathecal inflammation on CSF Exam (n=10)
Demographics
Age in years, mean (SD)	42.5 (15.8)	33.8 (12.0)
Sex (%female)	36.4%	70%	ns
Radiographic Features
Lesion Number
Solitary n(%)	5 (45.5%)	1 (10%)	P=0.15
Multifocal n(%)	6 (54.5%)	9 (90%)
Spinal Lesions n(%)	2 (22.2%)	3 (30%)	ns
Treatment
DMT n(%)	6 (66.7%)	8 (100%)	ns
Prognosis
Median follow-up in months	19.5	47	P=0.08
Clinical Relapse n(%)#	2/8 (25%)	4/6 (66.7%)	ns
MRI Progression n(%)	3/9 (33.3%)	4/6 (66.7%)	ns
Last EDSS, mean (SD)	2.8 (2.3)	4 (2.6)	ns

^#Patients with available follow-up.