Table 2. Mean and S.D. of meloxicam pharmacokinetic parameters after IV administration at 0.5 mg/kg in 6 buffalo calves.

Parameters	Unit	Mean	S.D.
AUC (0→∞)	h* μg/mL	118.81	27.57
t ½ K10	h	6.93	3.66
t ½ α	h	0.09*	0.06
t ½ β	h	21.51*	6.4
K10	1/h	0.13	0.09
K12	1/h	4.18	2.89
K21	1/h	1.75	1.61
C0	μg/mL	14.39	7.13
V1	mL/kg	40.51	15.16
ClB	mL/h/kg	4.38	0.95
AUMC(0→∞)	h*h* μg/mL	3991.78	1859.87
MRT(0→∞)	h	32.89	10.33
Vdss	mL/kg	142.31	55.08
V2	mL/kg	101.8	67.31
Vz	mL/kg	146.16	53.98

AUC _(0-∞) = area under serum concentration-time curve from 0 extrapolated to infinity; t ½ K10 = the half-life associated with the rate constant K10; t ½α = distribution half-life; t ½β = elimination half-life; K10 = the rate at which the drug leaves the system from the central compartment (the elimination rate); K12 = the rate at which the drug passes from central to peripheral compartment; K21 = the rate at which the drug passes from peripheral to central compartment; C0 = serum concentration at time 0; V1 = volume of distribution in the central compartment; Cl_B = body clearance; AUMC = area under moment curve; MRT = mean residence time; V_dss = volume of distribution at steady-state; curve; V2 = volume of distribution in the peripheral compartment; V_z = volume of distribution based on the terminal phase;

* = harmonic mean ± pseudo-deviation standard.