Table 2. CpG and UpA dinucleotides inhibit initiation of E7 replicon RNA replication.

RD cells
Mutated regions		EGFP positive (%)		Relative EGFP positive cells		Relative mean fluorescence intensity
Coding R2	ncR1	Average	SE	Average	SE	Average	SE
WT	WT	14.47	2.67	1.00	0.00	1.00	0.00
WT	P	12.84	3.23	0.89	0.11	1.09	0.29
WT	cu	10.33	1.70	0.72	0.03	1.02	0.17
WT	U	12.69	1.87	0.89	0.05	1.07	0.10
WT	C	6.62	1.47	0.49	0.15	0.97	0.21
C	WT	2.25	0.68	0.16	0.04	0.69	0.14
C	C	1.08	0.20	0.08	0.02	0.61	0.16
U	U	2.00	0.66	0.14	0.04	0.94	0.06

BHK cells
Mutated regions		EGFP positive (%)		Relative EGFP positive cells		Relative mean fluorescence intensity
Coding R2	ncR1	Average	SE	Average	SE	Average	SE
WT	WT	10.22	2.25	1.00	0.00	1.00	0.00
WT	P	8.09	1.10	0.83	0.13	1.21	0.20
WT	cu	11.16	2.02	1.17	0.31	1.21	0.17
WT	U	13.87	1.75	1.41	0.16	1.18	0.14
WT	C	7.75	2.90	0.78	0.33	0.97	0.11
C	WT	4.74	1.31	0.49	0.17	0.84	0.21
C	C	1.87	0.60	0.18	0.02	0.85	0.19
U	U	5.35	1.59	0.51	0.04	1.10	0.14