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. Author manuscript; available in PMC: 2018 Sep 19.
Published in final edited form as: J Am Coll Cardiol. 2017 Sep 19;70(12):1479–1492. doi: 10.1016/j.jacc.2017.07.762

Central Illustration. Cardioprotective Effects of Fv-HSP72 on Ischemia-reperfusion Injury.

Central Illustration

A single-chain variable fragment (Fv) of the 3E10 antibody transports heat shock protein (HSP)72 into cardiomyocytes through the equilibrative nucleoside transporter 2 (ENT2) channel, where the HSP inhibited apoptosis in a rabbit model of ischemia-reperfusion injury. Either moiety alone is not cardioprotective.