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. Author manuscript; available in PMC: 2018 Jan 13.
Published in final edited form as: ACS Infect Dis. 2016 Oct 27;3(1):54–61. doi: 10.1021/acsinfecdis.6b00123

Figure 5.

Figure 5

Evaluation of on-target antibacterial activity. Comparison of MIC of compounds with wild type S. aureus (red bars) and S. aureus strain overexpressing SaFabI (blue bars) to determine on-target antibacterial activity. Compounds with promising IC50s and MICs (with wild S. aureus) are shown here. The ≥4 fold increase in MIC with the SaFabI overexpression strain indicates antibacterial activity is the result of on-target inhibition as seen in the case of compounds 1, 9, and 10. Triclosan (TCL) is used as a control.