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. Author manuscript; available in PMC: 2017 Oct 27.
Published in final edited form as: Brain Stimul. 2014 Dec 3;8(3):645–654. doi: 10.1016/j.brs.2014.11.020

Figure 2.

Figure 2

Relationship between hippocampal, fornix, and mammillary body volume change in response to fornix DBS. (A) Relative changes in mean (i.e., average of right and left) fornix volume for each patient after one year of fornix DBS. (B) Relative changes in mean (i.e., average of right and left) mammillary body (MB) volume for each patient after one year of fornix DBS. (C) Hippocampal volume change and fornix volume change are highly correlated. (D) Hippocampal volume change and mammillary body volume change are also highly correlated. Taken together, the results in (C) and (D) support the notion of a circuit-wide neuroprotective effect of DBS in AD.