Table 2. T1 early rectal cancer features before endoscopic mucosal resection, indications for endoscopic full-thickness resection, and follow-up.

Patient #	Rectal site	Endoscopic features before EMR	Level of invasion of each ERC according to the EMR specimen	Positive Ueno’s criteria based on the en bloc EMR specimen	Indication for EFTR	Pre-EFTR staging based on Endoscopy, EUS, CT	Histology based on the en bloc EFTR specimens	Oncologic follow-up
1	Distal	30 mm, I s, Kudo V, negative lifting sign	sm3	Tumor budding, excision margin, Kikuchi’s level, width of submucosal invasion	Incomplete endoscopic excision of T1-ERC unfit for surgery (ASA IV)	T0, N0, M0	R0, full-thickness resection; histology negative for residual disease	Endoscopy, EUS, and CT negative at 3 and 12 months; Endoscopy and EUS negative at 18 months
2	Distal	20 mm, I sp, Kudo IIIL, negative lifting sign	sm3	Tumor budding, Haggitt’s level, excision margin, depth and width of submucosal invasion	Incomplete endoscopic excision of T1-ERC refusing surgery (ASA II)	T0, N0, M0	R0, full-thickness resection; histology negative for residual disease	Endoscopy, EUS and CT negative at 6 and 12 months
3	Distal	18 mm, I sp, Kudo IIIL, negative lifting sign	sm3	Haggitt’s level, excision margin, depth and width of submucosal invasion	Incomplete endoscopic excision of T1-ERC refusing surgery (ASA III)	T0, N0, M0	R0, complete submucosal resection but no muscularis propria layer in the specimen; histology negative for residual disease	Endoscopy, EUS and CT negative at 6 and 12 months
4	Proximal	6 mm, I s, Kudo V, negative lifting sign	sm3	Haggitt’s level, excision margin	Incomplete endoscopic excision of T1-ERC unfit for surgery (ASA IV)	T1, N0, M0	R0, full-thickness resection; histology positive for adenocarcinoma (sm2)	Endoscopy, EUS and CT negative at 6 months. Patient died from severe cardiac disease at the 8th follow-up month
5	Distal	7 mm, I s, Kudo IV, negative lifting sign	sm1	Low tumor differentiation grade, excision margin	Incomplete endoscopic excision of T1-ERC unfit for surgery (ASA IV)	T0, N0, M0	R0, full-thickness resection; histology negative for residual disease	Endoscopy, EUS and CT negative at 6 and 12 months
6	Distal	18 mm, I s, Kudo IIIL, negative lifting sign	sm1	Tumor budding, excision margin, width of submucosal invasion	Incomplete endoscopic excision of T1-ERC refusing surgery (ASA III)	T0, N0	R0, complete submucosal resection but no muscularis propria layer in the specimen; histology negative for residual disease	Endoscopy, EUS and CT negative at 6 and 12 months

ASA, physical status classification system adopted by the American Society of Anesthesiologists; EFTR, endoscopic full-thickness resection performed with the Full-Thickness Resection Device (FTRD ^® ) System; EMR, endoscopic mucosal resection; ERC, early rectal cancer; EUS, endoscopic ultrasound.