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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Transl Res. 2017 Jun 15;189:13–29. doi: 10.1016/j.trsl.2017.06.006

Figure 3. The Biosynthetic Pathways for Eicosanoids and Specialized Pro-Resolution Lipid Mediators (SPM).

Figure 3

The C1P/cPLA2α interaction at cellular membranes releases sn2 bound unsaturated fatty acids (AA, EPA, DHA) from membrane-bound phospholipids. Through interactions with cyclooxygenases, cytochrome P450, or lipoxygenases; AA, DHA, and EPA are converted into pro-inflammatory (red) or anti-inflammatory (green) lipid mediators.