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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Biochim Biophys Acta. 2017 Sep 12;1859(12):2319–2326. doi: 10.1016/j.bbamem.2017.09.008

Figure 3.

Figure 3

Cellular localization of protease activity. The antimicrobial peptides ARVA (A) and indolicidin (B) at 20 μM were incubated with the cytosolic extract of human red blood cells or the isolated, washed membrane fractions. The fraction of intact peptide remaining was assayed by HPLC. The results show that proteolytic activity is present in the cytosolic fraction, but not the membrane fraction. The small peptide loss in experiments where ARVA is incubated with membrane fractions can be explained by strong membrane binding.