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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Alcohol Clin Exp Res. 2017 Oct 3;41(11):1896–1906. doi: 10.1111/acer.13488

Figure 4.

Figure 4

A: Effects of microinjection of lentiviral shRNAs into the prelimbic cortex on alcohol drinking in male Wistar rats (n = 9–10/group) given continuous access (CA) for 5 weeks and intermittent access (IA) for 3 weeks to alcohol under a three-bottle choice condition (10% & 15% ethanol vs water). B: Effects of shRNAs on expression levels of Grm2 mRNA in vitro and mGlu2 receptor (mGluR2) protein in vivo. * p < 0.05, significantly lower than the ‘scrambled’ group. Inset: SG: scrambled; Sh1: shGrm2-972; Sh2: shGrm2-2344.