Table 1. Association of Varus Thrust at 12 months with Incident Radiographic Knee OA and with Medial Joint Space Narrowing in Knees without OA (at enrollment and 12 months) over up to 7 years Subsequent Follow-up.

In the first 2 rows, the table shows the frequency of knees with each outcome for the dichotomous outcomes (row percentage) and mean (SD) of change for the continuous outcome among knees with (first row) and without (second row) varus thrust. The third and fourth rows show adjusted odds ratios and 95% confidence intervals [OR (95% CI)] for thrust for each of the 3 dichotomous outcomes (first 3 columns) and the adjusted regression coefficients (95% CI) for the continuous outcome (fourth column).

	Frequencies (%) and Adjusted Odds Ratios (95% CI) 4187 knees [987 (23.6%) with thrust]			Means (SD) and Adjusted Regression Coefficients (95% CI) 1736 knees [425 (24.5%) with thrust]
	Dichotomous outcomes			Continuous outcome
	Incident KL≥2	Medial joint space narrowing, whole grade	Medial joint space narrowing, partial grade	Annualized loss of medial joint space width (mm), measured at x = 0.250 location
	n (%) with outcome			Mean (SD) annualized loss of medial joint space width
Varus thrust present (987 knees)	123 (12.5%)	68 (6.9%)	71 (7.2%)	Varus thrust present (425 knees)	0.092 (0.149)
Varus thrust absent (3200 knees)	370 (11.6%)	212 (6.6%)	226 (7.1%)	Varus thrust absent (1311 knees)	0.077 (0.151)
Model: Varus thrust, adj. for age, gender, BMI	1.09 (0.86, 1.37)	0.98 (0.73, 1.32)	0.96 (0.71, 1.28)	0.011 (−0.006, 0.028)
Model: Varus thrust, adj. for age, gender, BMI, WOMAC Pain	1.09 (0.86, 1.37)a	0.98 (0.73, 1.32)b	0.96 (0.72, 1.28)c	0.011 (−0.006, 0.028)d

^aAlso significant: BMI, gender (increased risk in women)

^bAlso significant: BMI

^cAlso significant: BMI

^dAlso significant: gender (decreased risk in women)