Table 3. Alignment Sub-study Data in Knees with OA (at enrollment or 12 months): Association of Varus Thrust with Medial Joint Space Narrowing, with and without Adjustment for Alignment, over up to 7 Years Subsequent Follow-up.

Findings from the 2 alignment sub-study samples are shown in the top (alignment by HKA) and bottom (alignment by FTA) half of the table. In the first 2 rows of each half, the table shows the frequency of knees with each outcome for the dichotomous outcomes (row percentage) and mean (SD) of change for the continuous outcome among knees with (first row) and without (second row) varus thrust. The third, fourth, and fifth rows show adjusted odds ratios and 95% confidence intervals [OR (95% CI)] for thrust for each of the 2 dichotomous outcomes (first 2 columns) and the adjusted regression coefficients (95% CI) for the continuous outcome (third column).

	Frequencies and Adjusted Odds Ratios (95% CI) for Thrust for Each Dichotomous Outcome		Means (SD) and Adjusted Regression Coefficients (95% CI) for Thrust for Continuous Outcome
	Medial joint space narrowing, whole grade	Medial joint space narrowing, partial grade	Annualized loss of medial joint space width (mm), measured at x = 0.250 location
Models and Covariates Including HKA	n = 2875 knees	n = 2875 knees	n = 3078 knees
Varus thrust present (806 knees)	152 (18.9%)	270 (33.5%)	Varus thrust present (906 knees)	0.176 (0.287)
Varus thrust absent (2069 knees)	295 (14.3%)	447 (21.6%)	Varus thrust absent (2172 knees)	0.117 (0.223)
Varus thrust, adj. for age, gender, BMI, WOMAC Pain	1.37 (1.09, 1.74)	1.76 (1.45, 2.15)	0.053 (0.031, 0.074)
Varus thrust, adj. for age, gender, BMI, WOMAC Pain + HKA	1.00 (0.78, 1.29)	1.27 (1.03, 1.58)	0.027 (0.006, 0.047)
Varus thrust, adj. for age, gender, BMI, WOMAC Pain + HKA and thrust-HKA interaction	1.16 (0.84, 1.60)a	1.56 (1.21, 2.01)b	0.020 (−0.001, 0.040)c
Models and Covariate Including FTA	n = 3378 knees	n = 3378 knees	n = 3608 knees
Varus thrust present (963 knees)	191 (19.8%)	327 (34.0%)	Varus thrust present (1073 knees)	0.174 (0.291)
Varus thrust absent (2415 knees)	345 (14.3%)	522 (21.6%)	Varus thrust absent (2535 knees)	0.117 (0.231)
Varus thrust, adj. for age, gender, BMI, WOMAC Pain	1.47 (1.19, 1.82)	1.80 (1.50, 2.16)	0.049 (0.029, 0.070)
Varus thrust, adj. for age, gender, BMI, WOMAC Pain + FTA	1.09 (0.87, 1.37)	1.28 (1.04, 1.56)	0.025 (0.005, 0.045)
Varus thrust, adj. for age, gender, BMI, WOMAC Pain + FTA and thrust-FTA interaction	1.77 (0.90, 3.52)d	3.04 (1.64, 5.63)e	0.007 (−0.039, 0.052)f

^aAlso significant: BMI, WOMAC Pain, HKA

^bAlso significant: Age, BMI, WOMAC Pain, HKA, interaction

^cAlso significant: WOMAC Pain, HKA

^dAlso significant: BMI, WOMAC Pain, FTA

^eAlso significant: Age, BMI, WOMAC Pain, FTA, interaction

^fAlso significant: gender (decreased risk in women), WOMAC Pain, FTA