Table 4. Alignment Sub-study Data in Knees with OA (at enrollment or 12 months): Association of Varus Thrust with Medial Joint Space Narrowing in Alignment (HKA) Strata over up to 7 Years Subsequent Follow-up.

In the first 2 rows of each section (alignment stratum), the table shows the frequency of knees with the dichotomous outcome (row percentage) and mean (SD) of change for the continuous outcome, among knees with and without varus thrust. The third row of each section shows adjusted odds ratios and 95% confidence intervals [OR (95% CI)] for thrust for the dichotomous outcome and the adjusted regression coefficients (95% CI) for the continuous outcome.

		Adjusted Odds Ratios (95% CI) for Thrust for Each Dichotomous Outcome	Adjusted Regression Coefficients (95% CI) for Thrust for Continuous Outcome
	Models and Covariates	Medial joint space narrowing, partial grade	Annualized loss of medial joint space width (mm), measured at x = 0.250 location
		n = 2875 knees  1242 varus 1112 neutral 521 valgus	n = 3078 knees  1373 varus 1129 neutral 576 valgus
Varus knees	% with outcome or outcome mean (SD), among varus knees with varus thrust	207/462 knees (44.8%)	0.216 (0.315) (n = 552 knees)
	% with outcome or outcome mean (SD) among varus knees without varus thrust	282/780 knees (36.2%)	0.170 (0.243) (n = 821 knees)
	Varus thrust, adj. for age, gender, BMI, WOMAC Pain	1.40 (1.08, 1.80)	0.041 (0.010, 0.073)
Neutral knees	% with outcome or outcome mean (SD) among neutral knees with varus thrust	59/248 knees (23.8%)	0.142 (0.238) (n = 249 knees)
	% with outcome or outcome mean (SD) among neutral knees without varus thrust	145/864 knees (16.8%)	0.098 (0.192) (n = 880 knees)
	Varus thrust, adj. for age, gender, BMI, WOMAC Pain	1.52 (1.06, 2.17)	0.045 (0.009, 0.080)
Valgus knees	% with outcome or outcome mean (SD) among valgus knees with varus thrust	4/96 (4.2%)	0.042 (0.159) (105 knees)
	% with outcome or outcome mean (SD) among valgus knees without varus thrust	20/425 (4.7%)	0.063 (0.219) (471 knees)
	Varus thrust, adj. for age, gender, BMI, WOMAC Pain	0.98 (0.32, 3.01)	−0.020 (−0.058, 0.017)