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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Pharmacol Biochem Behav. 2017 Aug 1;162:62–68. doi: 10.1016/j.pbb.2017.07.012

Figure 2.

Figure 2

Summary of the proposed input and output circuitry of the lateral habenula (LHb). The LHb receives a diverse range of context related information. This information is integrated to evaluate whether the ongoing behavior should be continued or replaced by an alternative one. Arrows adjacent to the LHb represent the proposed direction of neural responses signaling whether to continue or replace the ongoing behavior. This evaluative signal influences midbrain areas important for attention, stress, pain, and reward evaluation to influence behavior/strategy selection. Abbreviations are as follows: medial prefrontal cortex (mPFC), lateral preoptic area (LPO), vertical limb of the diagonal band of Broca (vDBB), lateral septal area (LSA), entopeduncular nucleus (EPN), ventral pallidum (VP), suprachiasmatic nucleus (SCN), lateral hypothalamus (LH), bed nucleus of the stria terminalis (BNST), dorsal raphe (DR), median raphe (MrN), substantia nigra pars compacta (SNc), ventral tegmental area (VTA), , rostromedial tegmental nucleus (RMTg), and the periaqueductal gray (PAG).