Table 1.
pK i values for the four PDE1 inhibitors
| Name | pK i (M) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| PDE1A | n | PDE1B | n | PDE1C | n | PDE5 | n | Other PDEs | |
| Lu AF58027 | 8.43 ± 0.12 | 4 | 7.75 ± 0.04 | 8 | 9.25 ± 0.08 | 6 | 6.04 ± 0.02 | 2 | PDE3, PDE4, PDE7 and PDE10, pK i ≈ 5 |
| Lu AF64196 | 7.24 ± 0.04 | 4 | 7.86 ± 0.05 | 9 | 7.33 ± 0.04 | 9 | <5 | 4 | All pK i < 5 |
| Lu AF66896 | 7.10 ± 0.10 | 3 | 8.31 ± 0.04 | 5 | 8.49 ± 0.08 | 5 | <5 | 3 | All pK i < 5 |
| Lu AF67897 | 7.00 ± 0.06 | 3 | 6.91 ± 0.05 | 6 | 8.19 ± 0.02 | 5 | <5 | 3 | Not broadly tested |
n is the number independent experimental determinations of pK i. Values are mean ± SEM.