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. 2017 Feb 1;174(22):4055–4069. doi: 10.1111/bph.13685

Figure 2.

Figure 2

AVE0991 decreases leukocyte infiltration in PVAT, but not visceral AT in ApoE−/− mice at 16, 20 and 24 weeks of age. (A) Flow cytometric analysis of total CD45+ leukocytes in the vascular stromal fraction isolated from PVAT of ApoE−/− and C57BL/6J mice treated with placebo or AVE0991. Representative examples are shown (above) and (below) as means ± SEM (n = 12 each group). (B) Representative flow cytometric analysis of leukocytes in vascular stromal fraction isolated from visceral fat (VAT). Absolute number of CD45+ total leukocyte content in VAT compartment are expressed as means ± SEM (n = 12 each). (C) Pie‐charts describing % composition of subpopulations of leukocytes infiltrating PVAT and in (D), leukocytes in VAT, from 24‐week‐old ApoE−/− mice fed placebo and after treatment with AVE0991. Leukocyte subpopulations were identified as described in Methods. P < 0.05, significantly different from C57BL/6J mice; * P < 0.05, significant effects of AVE0991.