Table 2.
Metabolite analysis of 18F-TFB in plasma and urine of healthy participants
| 40 mina | 145 mina | 235 mina | Accumulative | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Males | Females | Males | Females | Males | Females | Males | Females | ||
| Whole blood (SUV) | 3.0 ± 0.2 | 3.1 ± 0.9 | 2.1 ± 0.2 | 1.7 ± 0.4 | 1.7 ± 0.2 | 1.4 ± 0.4 | – | – | |
| Plasma (SUV) | 3.8 ± 0.2 | 3.8 ± 1.0 | 2.8 ± 0.3 | 2.1 ± 0.5 | 2.0 ± 0.1 | 1.7 ± 0.5 | – | – | |
| Urine (%dose) | 15 ± 2b | 16 ± 3 | 13 ± 3 | 18 ± 3 | 10 ± 2b | 12 ± 2 | 40 ± 5b | 46 ± 7 | |
| %Intact 18F-TFB | Plasma | 97 ± 2 | 97 ± 3c | −d | −d | −d | −d | – | – |
| Urine | 96 ± 2 | 98 ± 1 | 97 ± 2 | 98 ± 1 | 98 ± 1 | 97 ± 2 | – | – | |
Values are mean ± SD (n = 4)
aTime points are shown for blood samples; urine samples were collected ~ 10 min later
bNo urine in third collection of one male subject
cOne plasma sample was not used because precipitate was observed in the HPLC analysis
dMetabolite data were not obtained in second and third plasma samples analysis because the low radioactivity levels were below detection limit