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. 2017 Oct 23;8:1346. doi: 10.3389/fimmu.2017.01346

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Copyright © 2017 Ichii, Kimura, Okamura, Horino, Nakamura, Sasaki, Elewa and Kon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tubulointerstitial inflammation in unilateral ureter obstruction (UUO) kidneys. (A) Renal histopathology at day 7 after UUO. Masson’s trichrome stain. The dilations of renal pelvis (RP) and increase of fibrotic area (blue) are prominent in UUO kidneys compared to Cont kidneys. (B) The ratio of KW/BW and area of RP. Values = mean ± SE. A significant difference from the Cont is indicated by **(P < 0.01). n = 6 kidneys. (C) Immunohistochemistry for B220, CD3, Gr1, Iba1, BrdU, single strand DNA, Caspase3, and αSMA in UUO kidneys. Arrows indicate immune-positive cells. Bars = 20 µm. (D) The quantified indices of immunopositive cells. Values = mean ± SE. A significant difference from the Cont is indicated by **(P < 0.01). n = 6 kidneys.