Fig. 6.

Late arrival of CPNs leads to long-term deficit of sensory function and social behavior. a Experimental timeline. b Sensory-oriented behavior tests show deficit in adult rats with delayed CPN migration; n = 15 and 12 animals (Control and dnTCF4, respectively), Mann–Whitney. c Principal component (PC) analysis of variables from sensory tests separates animals with late-arrived neurons (dnTCF4) from controls. d Decreased sociability and interaction (sniffing) as well as increased tendency for repetitive movements (self-grooming) in animals with late-arrived CPNs; n = 18 and 11 animals (Control and dnTCF4, respectively), Mann–Whitney. e Plots of PC analysis of autistic-like variables. Graphs display mean ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001