Fig. 7.

Correcting CPN migration delay rescues the circuit and behavior phenotype. a Restored migration by C-Kit overexpression rescues axon arborization. Graphs show the average regional intensity in L5A and L2/3, n = 11 and 10 brains (Control and dnTCF4 + C-Kit, respectively), Mann–Whitney, P = 0.1971 for L5A and P = 0.7564 for L2/3. b Sociability, interaction (sniffing), and tendency for repetitive movements (self-grooming) are rescued by C-Kit overexpression; n = 18 and 13 animals (Control and dnTCF4 + C-Kit, respectively), Mann–Whitney, P = 0.1324 for social preference, P = 0.7004 for social novelty, P = 0.3167 for sniffing and P = 0.5736 for self-grooming. c PC analysis plots of autistic-like variables. Graphs display mean ± s.e.m. ns, non-significant. Bar = 100 μm