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. 2017 Oct 27;8:1174. doi: 10.1038/s41467-017-01224-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Limitation of OAS or sulfide for Cys biosynthesis results in decreased translation and distinct metabolic phenotype. a Metabolic pathway of cysteine biosynthesis. b Rosette phenotype of 7-week-old wild-type serat tko and sir1-1 grown in hydroponic culture. Scale bar, 2 cm. c Global translation rate in different genotypes as determined by time-resolved incorporation of ³H-glutamic acid into proteins (n = 3, mean ± s.e.m., one-way ANOVA, *p < 0.05). d Relative fold change of metabolites is depicted as a heat map in cysteine-synthesis-depleted mutants compared to wild type (n = 3–4, one-way ANOVA, *p < 0.05, **p < 0.01)