Table 1.

Summary measures of the genetic risk of 15 common cancers

	Obtained from Mucci et al.20
Site	h 2 (%)	env 2 (%)	AR (%)	λM	GC h 2	GC beta	RR20:20	RRinterv
Overall cancer	33.0	0.0	32.4	1.4	0.37	0.37	9	0.64
Head and neck	9.0	26.0	0.8	7.5	0.45	0.84	12	0.55
Stomach	22.0	6.0	1.1	6.2	0.64	0.81	66	0.34
Colon	15.0	16.0	2.9	3.8	0.48	0.71	16	0.51
Rectum and anus	14.0	10.0	1.9	3.5	0.49	0.68	17	0.50
Lung	18.0	24.0	3.2	5.5	0.52	0.80	22	0.48
Melanoma	58.0	0.0	1.2	16.3	0.90	0.93	69,946	0.05
Non-Melanoma	43.0	0.0	1.9	7.6	0.79	0.85	997	0.17
Breast	31.0	16.0	9.4	3.0	0.55	0.66	36	0.45
Corpus uteri	27.0	0.0	2.0	3.5	0.66	0.69	87	0.33
Ovary	39.0	0.0	1.6	5.4	0.78	0.79	610	0.19
Prostate	57.0	0.0	10.5	3.6	0.71	0.73	689	0.26
Testis	37.0	24.0	0.5	27.6	0.83	0.96	1339	0.13
Kidney	38.0	0.0	0.8	8.4	0.81	0.85	1049	0.15
Bladder, other urinary organs	30.0	0.0	2.2	4.5	0.68	0.75	120	0.30
Leukemia, other	57.0	0.0	0.6	25.3	0.92	0.95	181350	0.03

Summary measures of genetic cancer risk are displayed. Here, h ² denotes heritability of liability estimates, and env ² denotes the contribution of common environmental factors to the variance of liability. AR denotes the absolute risk of cancer, and λ_M denotes the recurrence risk in monozygotic co-twins. The four leftmost columns are obtained from Mucci et al.²⁰ GC _h2 denotes the Gini index derived from the heritability method. GC_beta denotes the Gini index derived from the beta distribution. RR_20:20 denotes the ratio of mean risks from the upper vs the lower 20 percentile. RR_interv describes the relative risk after an intervention in which those in the upper 20 percentile are manipulated to achieve the average risk in the lower 20 percentile