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. 2017 Oct 23;8:272. doi: 10.3389/fendo.2017.00272

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Copyright © 2017 Chamard-Jovenin, Thiebaut, Chesnel, Bresso, Morel, Smail-Tabbone, Devignes, Boukhobza and Dumond.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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M4 stimulating cell proliferation. (A) Quantification of MCF-10A cell viability by crystal violet assay after 24 h vehicle or 1 nM M4 exposure. M4 treatment triggered a 26% increase of cell proliferation. Each bar represents mean ± SD. N = 3. *p < 0.05. (B) Western blot analyses of protein expression level (left) and corresponding quantifications (right) of phospho-Src (tyr416), Cyclin B1, D1, E1 and phospho-Rb (retinoblastoma protein) in 24 h vehicle or 1 nM M4-treated cells. β-Actin was used as a loading control. Enhanced Src and Rb phosphorylation as well as Cyclin D1 and Cyclin E1 expression was observed under M4 treatment. Each bar represents mean ± SD. N = 4. *p < 0.05.