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(A,B) Images coupe de biopsie. Biopsy concluded to a ductal multicentric carcinoma in situ, nuclear grade 2–3, HER2 (+), ER, and PRG (−), classification as B5a. Microscopic examination of the specimen using H&E staining. (A) The epidermis of the nipple infiltrated by large Paget’s cells with pale abundant cytoplasm (magnification, ×100). (B) Single groups of Paget’s cells with vesicular nuclei and prominent nucleoli (magnification, ×400).
