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. 2017 Oct 23;4:177. doi: 10.3389/fmed.2017.00177

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Copyright © 2017 Kitagawa, Reynolds, Wehrens, Bryan and Pandit.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ratio of medial wall area: total vessel wall area as an index of vessel wall thickness in female TASK-1^−/− and wild-type C57BL/6 mice at 20 weeks and 1 year. Female TASK-1^−/− mice demonstrated a non-significant trend (p = 0.07, n = 6–7 animals per group) in decreased wall thickness compared to female wild-type mice at both 20 weeks and 1 year. There was no measurable age-related increase in wall thickness index in either genotype.