Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 23;4:177. doi: 10.3389/fmed.2017.00177

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Kitagawa, Reynolds, Wehrens, Bryan and Pandit.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Adult male TASK-1^−/− and wild-type mice (C57Bl/6) right ventricular systolic pressures (RVSP) in room air, 10% hypoxia for 3 weeks, then recovery to room air. Wild-type male mice exposed to hypoxia had a significant increase in RVSP hypoxia (*p < 0.05, n = 5) from baseline. Hypoxia-induced elevation in RVSP significantly decreased in recovery to room air (**p < 0.001, n = 6). TASK-1^−/− male mice also demonstrated a similar significant increase in RVSP hypoxia (*p < 0.05, n = 6) and that significantly decreased in recovery (**p < 0.01, n = 5). There was no difference between wild-type and TASK-1^−/− mice in the degree of increase in RVSP after exposure to hypoxia or the recovery decrease in RVSP.