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. 2017 Oct 23;4:177. doi: 10.3389/fmed.2017.00177

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Copyright © 2017 Kitagawa, Reynolds, Wehrens, Bryan and Pandit.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adult male TASK-1^−/− (KO) and wild-type mice (C57Bl/6) index of wall thickness in room air, 10% hypoxia for 3 weeks, then recovery to room air. Both wild-type (n = 5) and TASK-1^−/− (n = 5) animals in hypoxic conditions had increased index of wall thickness compared to baseline normoxia without any difference between genotypes (*p < 0.05, **p < 0.01, wild-type and TASK-1^−/−, respectively.) The index of wall thickness remained persistently elevated even in recovery in both genotypes.