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. 2017 Oct 23;8:818. doi: 10.3389/fphys.2017.00818

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Copyright © 2017 Yang, Nanayakkara, Drummer, Sun, Johnson, Cueto, Fu, Shao, Wang, Yang, Tang, Liu, Ge, Zhou, Khan, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiRNA in immune cell derived exosomes exert anti-inflammatory effects. (A) Graphical representation of how miRNA inhibit inflammation by promoting mRNA degradation and decreasing the expression of multiple mRNA targets. (B) The major pathways that are inhibited by the miRNA that are transported in exosomes derived from immune cells. (C) Venn analysis revealed that only 2 signaling pathways are shared by the anti-inflammatory cytokines and miRNA found in the exosomes generated by immune cells.