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. 2017 Oct 23;8:818. doi: 10.3389/fphys.2017.00818

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Copyright © 2017 Yang, Nanayakkara, Drummer, Sun, Johnson, Cueto, Fu, Shao, Wang, Yang, Tang, Liu, Ge, Zhou, Khan, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LIUS exerts anti-inflammatory effects in various cell-, animal- and clinical models by upregulating anti-inflammatory gene expression. (A) An extensive literature survey confirmed that ultrasound therapy exerts anti-inflammatory effects. (B) Schematic representation of the logic behind the microarray analysis we conducted to determine the anti-inflammatory gene expression. (C) The list of anti-inflammatory genes that are upregulated with LIUS, revealed by our data analysis. (D) The major signaling pathways regulated by the anti-inflammatory genes that are upregulated by LIUS.