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. 2017 Oct 23;8:818. doi: 10.3389/fphys.2017.00818

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Copyright © 2017 Yang, Nanayakkara, Drummer, Sun, Johnson, Cueto, Fu, Shao, Wang, Yang, Tang, Liu, Ge, Zhou, Khan, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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anti-inflammatory cytokines and miRNA found in immune cell derived exosomes have distinct cellular networks. (A) Cytoscape Network Visualization Analysis revealed that miRNA (red) and anti-inflammatory cytokine (green) have distinct cellular networks that are not shared (large spheres represent biological processes while small sphere indicates a gene/mRNA). (B) The major pathways that are regulated by the anti-inflammatory cytokines carried in exosomes derived from immune cells.