Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 27;8:1164. doi: 10.1038/s41467-017-01283-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — EphB1 and STAT3 expression patterns in the ventral horn of wild type and SOD1^G93A-ALS mice. a Schematic diagram and immunofluorescence images showing very low levels of EphB1 immunolabelling in ChAT-positive motor neurons (MNs) in the ventral horn (VH) of unlesioned wild type (WT) and SOD1-mutant mice. White boxes represent the corresponding cells magnified in the insets for each group. b Immunofluoresence demonstrating ALDH1L1-positive astrocytes (ACs) with nuclear STAT3 (nSTAT3) immunostaining (arrows) in unlesioned WT and SOD1-mutant mice. c Graph demonstrates the mean of the EphB1-labelled proportion of ChAT-positive motor neurons in the two groups (n = 4; p = 0.476, unpaired t-test). d Graph demonstrates the mean of the nSTAT3-labelled proportion of ALDH1L1-positive astrocytes in the two groups (n = 4; p = 0.821, unpaired t-test). e Schematic diagram and immunofluorescence images demonstrating EphB1 positivity (arrows) corresponding with ChAT-labelled motor neurons in the ipsilateral (IL) and contralateral (CL) VH of mice following right-sided sciatic nerve (SN) transection. f Graph shows the mean values of fold changes in the proportion of EphB1-labelled motor neurons in the IL VHs when normalised to the CL side (n = 4, p = 0.956 for day 1; n = 3, *p = 0.011 for day 7, unpaired t-test). g Schematic diagram and immunostained tissue sections demonstrating ALDH1L1-positive astrocytes with nSTAT3 IR (arrows). h Graph shows mean values of fold changes in the proportion of nSTAT3-positive astrocytes in the IL VHs normalised to the CL side (n = 3 controls, n = 4 SOD1, p = 0.227 for day 1; n = 4, *p = 0.010 for day 7, unpaired t-test). Data is expressed as mean ± SEM. Scale bar: 40 μm (20 μm for insets)