Fig. 2.

Recognition memory of 4- to 5-month-old wild-type and APP/PS1 transgenic mice (n = 11 per group) was quantitatively determined within an open arena using the novel ORT paradigm. In the acquisition phase of the behavioural task a the recognition indices (RI) were not significantly different for either wild-type or APP/PS1 transgenic mice thus showing similar exploration of either object within the open arena. After a 3-h time delay between the acquisition and test phase when mice were reintroduced into the arena and exposed to the familiar and novel object the RI was significantly greater for the novel object demonstrating a significantly greater exploration of novelty by both groups of mice (p < 0.05; b). Statistical analysis was conducted using two-way ANOVA with Bonferroni’s multiple comparison test and data is presented as mean ± SEM