Fig. 5.

Representative scanning electron micrographs of resin-casted hepatic vasculature of the left hepatic lobe within 4- to 5-month-old wild-type (a) or APP/PS1 (b) mice (n = 6 per group). The hepatic angioarchitecture on the serosal surface of the left lobe consists of a network of interconnected vessels that have uniform diameters (a). The hepatic vasculature on the left lobe serosal surface of age-matched APP/PS1 mice contained areas of vessel elimination that were surrounded by densely crowded vessels (b). A quantitative evaluation of murine hepatic vessel number revealed a highly significant reduction in the number of hepatic sinusoidal vessels in APP/PS1 transgenic mice when compared to age-matched wild-type littermates (***p = 0.0002; c). Statistical analysis was conducted using an unpaired t test and data are presented as mean ± SEM. Scale bar 100 µm