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. 2017 Oct 27;7:14240. doi: 10.1038/s41598-017-14694-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dual LSPR-SERS specific detection of anti-human IgG. (A) Simulated relationship between the spectral position of reflectance spectra and the refractive index. The line is a linear fit, with the sensitivity determined to be 195 nm/RIU. (B) Reflectance response after human IgG immobilization and specific anti-human IgG detection. (C) Normal Raman spectrum of solid human IgG (black spectrum) and SERS spectra of human IgG-immobilized flexible Au PDMS PS 710 nanoplatform before (red spectrum) and after (blue spectrum) anti-human IgG attachment.