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. 2017 Oct 27;7:14275. doi: 10.1038/s41598-017-14290-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment with ACVR2B/Fc restores deficits in body weight, grip strength and muscle mass in R6/2 mice. (A) ACVR2B/Fc treatment resulted in a progressive weight gain in both WT and R6/2 mice and prevented body weight loss in R6/2 mice. (B) ACVR2B/Fc treatment resulted in a progressive increase in fore-limb grip strength in both WT and R6/2 mice and prevented grip strength deficits in R6/2 mice. (C) Treatment with ACVR2B/Fc increased muscle mass in both WT and R6/2 mice with the consequence that the R6/2 muscle mass at 12 weeks of age (genders combined) is equivalent to that of wild type mice for quadriceps, gastrocnemius and tibialis anterior hind limb skeletal muscles. Statistical analysis was two-way ANOVA with post-hoc Bonferroni correction (see Table S8 for main effects and Table S9 for multiple comparisons). The statistical significance between values for ACVR2B/Fc treated and vehicle treated R6/2 mice is depicted: *p < 0.05; **p < 0.01; ***p < 0.001. n = 5 mice per gender per genotype. All data presented as means ± SEM.