Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 27;7:14275. doi: 10.1038/s41598-017-14290-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Treatment with ACVR2B/Fc delays end-stage disease, but has no effect on rotarod performance or activity measures. (A) ACVR2B/Fc treatment completely prevented the progressive loss in body weight loss that occurs in R6/2 mice. The effect was such that R6/2 mice were significantly heavier than WT mice at some ages (Table S9). (B) Kaplan-Meier curve showing that ACVR2B/Fc treatment delays end-stage disease in R6/2 mice (Chi = 8.764, p < 0.01 Mantel-Cox log-rank test). (C) ACVR2B/Fc treatment completely prevented the progressive loss in fore-limb as well as the combined fore- and hind-limb grip strength that occurs in R6/2 mice. The effect was such that R6/2 mice were significantly stronger than WT mice at some ages (Table S9) (D) ACVR2B/Fc had no effect on the impairment in R6/2 rotarod performance or hypoactivity. Statistical analysis was two-way ANOVA with post-hoc Bonferroni correction (see Table S8 for main effects and Table S9 for multiple comparisons). The statistical significance between values for ACVR2B/Fc treated and vehicle treated R6/2 mice is depicted: *p < 0.05; **p < 0.01; ***p < 0.001. WT vehicle, n = 13; R6/2 vehicle, n = 17; R6/2 ACVR2B/Fc, n = 14. All data presented as means ± SEM.